4. Unlock human resilience

Adapt the body’s immune system and other protections to thrive in a changing environment

4.1 Personalized defense

Understand the immune microbe interface to improve individuals' ability to guard against infection and illnesses by tailoring diagnostic prevention and therapeutic techniques, e.g., define how nutrition impacts immune system functionality

4.2 Inflammation as a driver of chronic disease

Drive research into the causation of chronic inflammation and its role in disease development (cancer, arthritis, diabetes, obesity, COPD, etc.) to develop improved diagnostic, prevention and therapeutic approaches

4.3 Health and performance in challenging environments

Drive exploration of healthy living and working in extreme conditions (heat, air impurities, toxicants, etc.) to build out new care models and technologies

4.4 Drivers of resilience and well-being

Study the behavioral, social, psychological, molecular and genetic determinants of increased well-being and resilience to disease and infection, e.g., study the impact of a stable adult relationship on a child's resilience

4.5 Disease prediction and containment

Utilize cutting-edge techniques for data collection and analytics to inform and collaborate with partner organizations to better predict, identify and contain emerging public health threats, e.g., rapid risk modeling and communication to create early warning systems

4.6 Outbreak prediction and containment

Interpret and share health data and analytics to state and national partners to better predict, identify and contain outbreaks, e.g., rapid modeling and analysis of the next superbug outbreak to inform CDC resource distribution